Our research is focused primarily around the ‘extended memory circuit’, shown below. We are particularly interested in how midline thalamus acts as a nexus to link executive and associational areas with the hippocampus and entorhinal cortex. We take a combined systems and cellular / synaptic approach, using in vivo electrophysiology, patch clamp recordings, behaviour and circuit tracing. We have a keen interest in neuronal oscillations and have recently begun working with human as well as animal data.
Our work spans fundamental biology through to translational models of neurodegeneration (Alzheimer’s & Lewy body dementias plus demyelinating disorders), genetic risk of schizophrenia (particularly CNV models) and models of depression and anhedonia. We are particularly interested in developing new translationals models of chronic neuroinflammation and using viral vectors to model neurodegenerative diseases.
Craig Lab 